Platelets play a key role in controlling the first phase of haemostasis. In recent years, the identification of some special molecules inside them - known as Platelet Growth Factors - has revealed new perspectives and possible applications in the medical and surgical field.
Numerous biochemical studies have shown a growth-stimulatory effect on different cell lines, with platelets acting as metabolic inducers: they release growth factors that immediately come into action, stimulating the regeneration of damaged tissues, and significantly accelerating the healing process.
Each of these identified factors targets a specific cell line (skin, muscle, ligaments and tendons, bone, blood vessels), acting on the metabolism of the treated tissue with a synergistic, anti-inflammatory and reparative action.
Growth factors are locally and constantly released through continuous platelet degranulation.
Growth factors main properties are listed below:
Several studies suggest that the use of a platelet concentrate, either alone or combined with other surgical techniques, or even as a support to implant devices, improves the final success of operations, significantly increasing patient’s comfort by reducing healing time.
In dentistry, the APG® method is used for:
In all these treatments, the adhesive nature of APG® facilitates the handling of implant material, improving hemostasis and wound closure compared to the traditional technique.
Furthermore, recent studies have shown that the use of platelet-rich plasma increases microvascular proliferation in the early stages of healing, followed by a better osteoblastic activity.
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