ACTIGEN

The concepts and ideas underlying the SLA and DAE surfaces represented a significant advance in the conception of implant fixtures, however they have not yet solved the problem of positioning implant devices in immediate post-extraction sockets at the level of which there is little primary stability.

In fact, osseointegration is favored by the initial mechanical stability subsequently strengthened by biological stability.

Why choose ACTIGEN

  1. It reduces the possibility of compromising the implant as it helps speed up osseointegration;
  2. Stimulates platelet activity;
  3. Prepares the surface of the implants to be rapidly colonized by the bone;
  4. Increases the bone-implant contact area; It decreases post-operative discomfort because it shortens the healing time;
  5. Limits the risk of implant surgery failure as it improves the quality and quantity of bone generated;
  6. It is a safe device, in fact it is the only bioactive treatment that meets the standards that allow inclusion in class 3.

Biocompatibility and osteoinductive capacity

Starting from today's implant coating technologies, UBGEN has invested in the search for a biological surface aimed at accelerating and increasing the osseointegrative process of the implant fixture.

The topography and chemical composition of the surface are used as a tool to target cellular behavior and therefore the process of bone regeneration.

For some time now, there has been talk of the possibility of activating implant surfaces through their functionalization with various biologically active molecules for bone formation: from synthetic peptides, to growth factors, to others.

ACTIGEN: the evolution of the implant coating

The most significant result in terms of osseointegration has been achieved by immobilising collagen of dermal origin (type I) on etched surfaces since the same type of collagen already constitutes to a large extent the organic portion of the bone and supports its vital processes.

In the regenerative processes, in fact, the osteoblastic cells initially deposit a collagen matrix which is then mineralized.

This collagen matrix exerts a series of positive biological effects: the adhesion of osteoblasts and osteoclasts, is a cofactor for many growth factors and many other mechanisms.

For UBGEN the use of collagen was a decisive choice in order to create a biological solution that anticipates future needs in the world of dentistry.

The angiogenic process

Immagine 1
Angiogenesis

Collagen plays a chemotactic action on the cell line of monocytes/macrophages, from which osteoclasts derive. These cells in turn stimulate angiogenesis, thanks to the secretion of angiogenic growth factors. Collagen is also able to activate the receptors on the cellular membrane of the platelets, thus facilitating haemostasis.

Immagine 2
Remodeling

Collagen stimulates a chemoattractant action on the precursors of osteoclasts, cells that through their action reabsorb the mineral component and collaborate with the osteoblasts in the rearrangement and remodelling of the bone in which the implant is placed.

Immagine 3
Osteoblastic activity

Collagen, by binding itself to fibronectin, promotes the anchoring of mesenchymal stem progenitor cells on which it exercises its chemotactic activity and induces the osteoblastic differentiation.

Immagine 4
Osteoconduction and guided regeneration

Collagen is able both to increase osteoblast proliferation speed and to guide the connective tissue regeneration.

We certify that the entire range of medical devices described above is CE marked and manufactured in accordance with the requirements of Directive 93/42 / EEC implemented in Italy with the DLGS. n. 46 dated 24-02-97 and subsequent amendments. The company operates in compliance with UNI EN ISO 9001 standards.

UBGEN Srl Viale del Lavoro 14, 35010, Vigonza (PD), Italy - Phone: +39 049 628 630

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